Purpose: To evaluate the stress level of second-yearâ��s nursing students during their first oncology clinical experience. Methods: The descriptive study in order to determine the stress levels of second-yearâ��s nursing students. This study was conducted with the students of Uludag University. The study population was consisting of 156 nursing students attending second year class in nursing school. Pagana Clinical Stress Questionnaire (PCSQ) was used. Data in analysis of surveyâ��s results was evaluated mean, Pearson's correlation method, t-test was used in statistical analysis percentage. Results: When a comparison is made between the mean score of clinical stress and socio-economic data of the students involved in the study; any meaningful difference has not been observed between the mean scores of stress and the sex, approaches to nursing profession, previous hospital experiences, health status whether having a chronic disease or not. Only meaningful difference (p>0.05) has been observed with family member status whether working as a health worker or not (p<0.05). The mean score of stress of students in the first clinical practice was found as 70 �± 4.15. This result exhibited that the students experienced stress is the average. Conclusions: It was found that the nursing students had a high level of stress during the first clinical practice and experienced the most stress \"fighting\" dimension from the subscales. So, it was thought that the clinical orientation program must be done before student experience. Because clinical orientation program was effective to reduce the risk.
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